2NQP
Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0001522 | biological_process | pseudouridine synthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006396 | biological_process | RNA processing |
| A | 0008033 | biological_process | tRNA processing |
| A | 0009451 | biological_process | RNA modification |
| A | 0009982 | molecular_function | pseudouridine synthase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0031119 | biological_process | tRNA pseudouridine synthesis |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0106029 | molecular_function | tRNA pseudouridine synthase activity |
| A | 0140098 | molecular_function | catalytic activity, acting on RNA |
| A | 0160147 | molecular_function | tRNA pseudouridine(38-40) synthase activity |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0001522 | biological_process | pseudouridine synthesis |
| B | 0003723 | molecular_function | RNA binding |
| B | 0006396 | biological_process | RNA processing |
| B | 0008033 | biological_process | tRNA processing |
| B | 0009451 | biological_process | RNA modification |
| B | 0009982 | molecular_function | pseudouridine synthase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0031119 | biological_process | tRNA pseudouridine synthesis |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0106029 | molecular_function | tRNA pseudouridine synthase activity |
| B | 0140098 | molecular_function | catalytic activity, acting on RNA |
| B | 0160147 | molecular_function | tRNA pseudouridine(38-40) synthase activity |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0001522 | biological_process | pseudouridine synthesis |
| C | 0003723 | molecular_function | RNA binding |
| C | 0006396 | biological_process | RNA processing |
| C | 0008033 | biological_process | tRNA processing |
| C | 0009451 | biological_process | RNA modification |
| C | 0009982 | molecular_function | pseudouridine synthase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0031119 | biological_process | tRNA pseudouridine synthesis |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0106029 | molecular_function | tRNA pseudouridine synthase activity |
| C | 0140098 | molecular_function | catalytic activity, acting on RNA |
| C | 0160147 | molecular_function | tRNA pseudouridine(38-40) synthase activity |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0001522 | biological_process | pseudouridine synthesis |
| D | 0003723 | molecular_function | RNA binding |
| D | 0006396 | biological_process | RNA processing |
| D | 0008033 | biological_process | tRNA processing |
| D | 0009451 | biological_process | RNA modification |
| D | 0009982 | molecular_function | pseudouridine synthase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0031119 | biological_process | tRNA pseudouridine synthesis |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0106029 | molecular_function | tRNA pseudouridine synthase activity |
| D | 0140098 | molecular_function | catalytic activity, acting on RNA |
| D | 0160147 | molecular_function | tRNA pseudouridine(38-40) synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K F 77 |
| Chain | Residue |
| F | U60 |
| F | C62 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K F 78 |
| Chain | Residue |
| F | G49 |
| F | G59 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K F 79 |
| Chain | Residue |
| F | U54 |
| F | U55 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K C 271 |
| Chain | Residue |
| C | ALA89 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K F 80 |
| Chain | Residue |
| F | K81 |
| F | U20 |
| F | A20 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K F 81 |
| Chain | Residue |
| F | U20 |
| F | U48 |
| F | G59 |
| F | U60 |
| F | K80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Region: {"description":"RNA binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"17466622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10588695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9425056","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17466622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with tRNA; Important for base-flipping","evidences":[{"source":"PubMed","id":"17466622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Site: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"17466622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dj0 |
| Chain | Residue | Details |
| A | ASP60 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dj0 |
| Chain | Residue | Details |
| B | ASP60 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dj0 |
| Chain | Residue | Details |
| C | ASP60 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dj0 |
| Chain | Residue | Details |
| D | ASP60 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 493 |
| Chain | Residue | Details |
| B | ARG58 | electrostatic stabiliser |
| B | ASP60 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | ARG205 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 493 |
| Chain | Residue | Details |
| C | ARG58 | electrostatic stabiliser |
| C | ASP60 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| C | ARG205 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 493 |
| Chain | Residue | Details |
| D | ARG58 | electrostatic stabiliser |
| D | ASP60 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| D | ARG205 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 493 |
| Chain | Residue | Details |
