Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 501 |
| Chain | Residue |
| A | ASP60 |
| A | HOH1060 |
| A | HOH1064 |
| A | HOH1068 |
| A | HOH1127 |
| A | HOH1132 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 502 |
| Chain | Residue |
| B | HOH1135 |
| B | HOH1190 |
| B | ASP160 |
| B | HOH1080 |
| B | HOH1112 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 503 |
| Chain | Residue |
| A | THR74 |
| A | ASN88 |
| A | HOH1147 |
| A | HOH1159 |
| B | ARG141 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 504 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 505 |
| Chain | Residue |
| B | THR174 |
| B | ASN188 |
| B | HOH1023 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ROC A 401 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | THR80 |
| A | PRO81 |
| A | HOH1002 |
| A | HOH1011 |
| A | HOH1032 |
| B | ARG108 |
| B | LEU123 |
| B | ASP125 |
| B | GLY127 |
| B | ASP129 |
| B | ASP130 |
| B | ILE147 |
| B | GLY148 |
| B | GLY149 |
| B | ILE150 |
| B | THR180 |
| B | PRO181 |
| B | VAL184 |
| B | HOH1001 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 601 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH1160 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | ARG87 |
| A | HOH1020 |
| A | HOH1048 |
| A | HOH1184 |
| B | TRP106 |
| B | ARG108 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 604 |
| Chain | Residue |
| A | GLY94 |
| B | TRP142 |
| B | LYS155 |
| B | VAL156 |
| B | ARG157 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | THR126 | |
| B | ASP125 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP125 | |
