2NNJ
CYP2C8dH complexed with felodipine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002933 | biological_process | lipid hydroxylation |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005886 | cellular_component | plasma membrane |
A | 0006082 | biological_process | organic acid metabolic process |
A | 0006805 | biological_process | xenobiotic metabolic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0008210 | biological_process | estrogen metabolic process |
A | 0008392 | molecular_function | arachidonic acid epoxygenase activity |
A | 0008401 | molecular_function | retinoic acid 4-hydroxylase activity |
A | 0016020 | cellular_component | membrane |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
A | 0019369 | biological_process | arachidonic acid metabolic process |
A | 0019373 | biological_process | epoxygenase P450 pathway |
A | 0020037 | molecular_function | heme binding |
A | 0034875 | molecular_function | caffeine oxidase activity |
A | 0042178 | biological_process | xenobiotic catabolic process |
A | 0042572 | biological_process | retinol metabolic process |
A | 0042573 | biological_process | retinoic acid metabolic process |
A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046456 | biological_process | icosanoid biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0070330 | molecular_function | aromatase activity |
A | 0070989 | biological_process | oxidative demethylation |
A | 0097267 | biological_process | omega-hydroxylase P450 pathway |
A | 0101020 | molecular_function | estrogen 16-alpha-hydroxylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 503 |
Chain | Residue |
A | ARG125 |
A | GLY332 |
A | ARG333 |
A | HIS334 |
A | HOH670 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 504 |
Chain | Residue |
A | ARG132 |
A | ASN133 |
A | HOH560 |
A | HOH631 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 505 |
Chain | Residue |
A | VAL330 |
A | ILE331 |
A | ARG335 |
A | HOH578 |
A | HOH579 |
site_id | AC4 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEM A 500 |
Chain | Residue |
A | ARG97 |
A | ILE112 |
A | TRP120 |
A | ARG124 |
A | ALA297 |
A | GLY298 |
A | THR301 |
A | THR302 |
A | LEU361 |
A | VAL366 |
A | HIS368 |
A | PRO427 |
A | PHE428 |
A | SER429 |
A | ARG433 |
A | CYS435 |
A | ALA436 |
A | 225501 |
A | HOH583 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 225 A 501 |
Chain | Residue |
A | VAL296 |
A | THR301 |
A | GLY365 |
A | VAL366 |
A | HEM500 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PLM A 502 |
Chain | Residue |
A | ILE106 |
A | PHE226 |
A | PRO227 |
A | GLY228 |
A | THR229 |
A | HIS230 |
A | LEU234 |
A | HOH660 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICAG |
Chain | Residue | Details |
A | PHE428-GLY437 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: |
Chain | Residue | Details |
A | SER100 | |
A | ASN204 | |
A | ARG241 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | CYS435 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER100 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1akd |
Chain | Residue | Details |
A | GLU300 | |
A | THR301 |