2N8H
Structural basis for the inhibition of voltage-gated sodium channels with conotoxin-muOxi-GVIIJ
Functional Information from PROSITE/UniProt
| site_id | PS00261 |
| Number of Residues | 7 |
| Details | GLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CSGFCdS |
| Chain | Residue | Details |
| A | CYS18-SER24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"24497506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Functionally important residue, that binds to the site 8 of the channel","evidences":[{"source":"PubMed","id":"26817840","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Functionally important residue, that binds to the site 8 of the channel (distinct surface that K-59; R-61 and Y-63)","evidences":[{"source":"PubMed","id":"26817840","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"6'-bromotryptophan","evidences":[{"source":"PubMed","id":"24497506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"24497506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
