2N70
Two-fold symmetric structure of the 18-60 construct of S31N M2 from Influenza A in lipid bilayers
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER123-LEU143 | |
| B | SER223-LEU243 | |
| C | SER323-LEU343 | |
| D | SER423-LEU443 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | HIS137 | |
| B | HIS237 | |
| C | HIS337 | |
| D | HIS437 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | TRP141 | |
| B | TRP241 | |
| C | TRP341 | |
| D | TRP441 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER250 | |
| C | SER350 | |
| D | SER450 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | ASN120 | |
| B | ASN220 | |
| C | ASN320 | |
| D | ASN420 |
