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2N02

Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195

Functional Information from GO Data
ChainGOidnamespacecontents
A0005497molecular_functionandrogen binding
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006694biological_processsteroid biosynthetic process
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0006869biological_processlipid transport
A0008347biological_processglial cell migration
A0008503molecular_functionbenzodiazepine receptor activity
A0009410biological_processresponse to xenobiotic stimulus
A0010042biological_processresponse to manganese ion
A0010266biological_processresponse to vitamin B1
A0010823biological_processobsolete negative regulation of mitochondrion organization
A0014012biological_processperipheral nervous system axon regeneration
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0030325biological_processadrenal gland development
A0031397biological_processnegative regulation of protein ubiquitination
A0031966cellular_componentmitochondrial membrane
A0032570biological_processresponse to progesterone
A0032720biological_processnegative regulation of tumor necrosis factor production
A0033574biological_processresponse to testosterone
A0042632biological_processcholesterol homeostasis
A0043065biological_processpositive regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0044325molecular_functiontransmembrane transporter binding
A0045019biological_processnegative regulation of nitric oxide biosynthetic process
A0048265biological_processresponse to pain
A0048266biological_processbehavioral response to pain
A0048678biological_processresponse to axon injury
A0050810biological_processregulation of steroid biosynthetic process
A0051901biological_processpositive regulation of mitochondrial depolarization
A0051928biological_processpositive regulation of calcium ion transport
A0060242biological_processcontact inhibition
A0060252biological_processpositive regulation of glial cell proliferation
A0060253biological_processnegative regulation of glial cell proliferation
A0062100biological_processpositive regulation of programmed necrotic cell death
A0071222biological_processcellular response to lipopolysaccharide
A0071294biological_processcellular response to zinc ion
A0071476biological_processcellular hypotonic response
A0072655biological_processestablishment of protein localization to mitochondrion
A0072656biological_processmaintenance of protein location in mitochondrion
A1901525biological_processnegative regulation of mitophagy
A1903579biological_processnegative regulation of ATP metabolic process
A1905144biological_processresponse to acetylcholine
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2000853biological_processnegative regulation of corticosterone secretion
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PKA A 201
ChainResidue
AGLY19
ATRP107
AALA110
ATRP143
AASN151
AGLY22
AALA23
ALYS39
AHIS43
AARG46
ALEU49
AILE52
ATRP53

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:24653034
ChainResidueDetails
AMET1-TRP5
ATRP68-MET79
AHIS127-ALA134

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
AVAL6-VAL26

site_idSWS_FT_FI3
Number of Residues36
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24653034
ChainResidueDetails
AARG27-ARG46
AGLY101-MET105
AARG156-GLU169

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
ATRP47-VAL67

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
AVAL80-PHE100

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
AGLY106-TRP126

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
AARG135-TRP155

218853

PDB entries from 2024-04-24

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