2MXC
Solution structure of the full length sorting nexin 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009617 | biological_process | response to bacterium |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010314 | molecular_function | phosphatidylinositol-5-phosphate binding |
| A | 0010324 | biological_process | membrane invagination |
| A | 0010976 | biological_process | positive regulation of neuron projection development |
| A | 0015031 | biological_process | protein transport |
| A | 0019903 | molecular_function | protein phosphatase binding |
| A | 0022615 | biological_process | protein to membrane docking |
| A | 0030111 | biological_process | regulation of Wnt signaling pathway |
| A | 0030136 | cellular_component | clathrin-coated vesicle |
| A | 0030904 | cellular_component | retromer complex |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0032009 | cellular_component | early phagosome |
| A | 0032266 | molecular_function | phosphatidylinositol-3-phosphate binding |
| A | 0032456 | biological_process | endocytic recycling |
| A | 0034499 | biological_process | late endosome to Golgi transport |
| A | 0035091 | molecular_function | phosphatidylinositol binding |
| A | 0042177 | biological_process | negative regulation of protein catabolic process |
| A | 0045335 | cellular_component | phagocytic vesicle |
| A | 0046597 | biological_process | host-mediated suppression of symbiont invasion |
| A | 0050765 | biological_process | negative regulation of phagocytosis |
| A | 0051224 | biological_process | negative regulation of protein transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0070676 | biological_process | intralumenal vesicle formation |
| A | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| A | 1901981 | molecular_function | phosphatidylinositol phosphate binding |
| A | 1905394 | molecular_function | retromer complex binding |
| A | 2000642 | biological_process | negative regulation of early endosome to late endosome transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Domain: {"description":"PX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00147","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"Binds predominantly to PtdIns(P5) and weaker to PtdIns(P3) abd PtdIns(P4); involved in neurite outgrowth regulation","evidences":[{"source":"UniProtKB","id":"O70492","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
