2MUB
Solution structure of the analgesic sea anemone peptide APETx2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0008200 | molecular_function | ion channel inhibitor activity |
A | 0015459 | molecular_function | potassium channel regulator activity |
A | 0017080 | molecular_function | sodium channel regulator activity |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0042151 | cellular_component | nematocyst |
A | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Important in ability to inhibit ASIC3 => ECO:0000269|PubMed:22851922 |
Chain | Residue | Details |
A | GLY1 | |
A | THR2 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Important in ability to inhibit Kv11.1/KCNH2/ERG1 => ECO:0000269|PubMed:25337890 |
Chain | Residue | Details |
A | ASN8 | |
A | PRO18 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Important in ability to inhibit ASIC3 => ECO:0000269|PubMed:22851929, ECO:0000305|PubMed:15987885 |
Chain | Residue | Details |
A | PHE15 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Important in ability to inhibit ASIC3 => ECO:0000269|PubMed:25337890, ECO:0000305|PubMed:15987885 |
Chain | Residue | Details |
A | TYR16 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Important in ability to inhibit ASIC3 => ECO:0000269|PubMed:20813121, ECO:0000269|PubMed:25337890, ECO:0000305|PubMed:15987885 |
Chain | Residue | Details |
A | ARG17 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Probably important in ability to inhibit ASIC3 => ECO:0000305|PubMed:25337890 |
Chain | Residue | Details |
A | ARG24 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Interacts with ASIC3 => ECO:0000305|PubMed:15987885 |
Chain | Residue | Details |
A | ARG31 | |
A | TYR32 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Important in ability to inhibit both ASIC3 and Kv11.1/KCNH2/ERG1 => ECO:0000269|PubMed:25337890, ECO:0000305|PubMed:15987885 |
Chain | Residue | Details |
A | PHE33 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | SITE: Important in ability to inhibit both ASIC3 and Kv11.1/KCNH2/ERG1 => ECO:0000269|PubMed:25337890 |
Chain | Residue | Details |
A | LEU34 |