2MUB
Solution structure of the analgesic sea anemone peptide APETx2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008200 | molecular_function | ion channel inhibitor activity |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0017080 | molecular_function | sodium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Region: {"description":"Play an important role in the folding and structural integrity of APETx2","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important in ability to inhibit ASIC3","evidences":[{"source":"PubMed","id":"22851922","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important in ability to inhibit Kv11.1/KCNH2/ERG1","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important in ability to inhibit ASIC3","evidences":[{"source":"PubMed","id":"22851929","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15987885","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important in ability to inhibit ASIC3","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15987885","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important in ability to inhibit ASIC3","evidences":[{"source":"PubMed","id":"20813121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15987885","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Probably important in ability to inhibit ASIC3","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interacts with ASIC3","evidences":[{"source":"PubMed","id":"15987885","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important in ability to inhibit both ASIC3 and Kv11.1/KCNH2/ERG1","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15987885","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important in ability to inhibit both ASIC3 and Kv11.1/KCNH2/ERG1","evidences":[{"source":"PubMed","id":"25337890","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
