2MT6

Solution structure of the human ubiquitin conjugating enzyme Ube2w

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006513	biological_process	protein monoubiquitination
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070979	biological_process	protein K11-linked ubiquitination
A	0071218	biological_process	cellular response to misfolded protein
A	0140374	biological_process	antiviral innate immune response
A	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	148
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23560854","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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