2MSD
NMR data-driven model of GTPase KRas-GNP tethered to a lipid-bilayer nanodisc
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0006869 | biological_process | lipid transport |
A | 0008289 | molecular_function | lipid binding |
A | 0042157 | biological_process | lipoprotein metabolic process |
B | 0000139 | cellular_component | Golgi membrane |
B | 0000165 | biological_process | MAPK cascade |
B | 0001934 | biological_process | positive regulation of protein phosphorylation |
B | 0003924 | molecular_function | GTPase activity |
B | 0003925 | molecular_function | G protein activity |
B | 0005515 | molecular_function | protein binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005741 | cellular_component | mitochondrial outer membrane |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005925 | cellular_component | focal adhesion |
B | 0007165 | biological_process | signal transduction |
B | 0007265 | biological_process | Ras protein signal transduction |
B | 0008283 | biological_process | cell population proliferation |
B | 0008542 | biological_process | visual learning |
B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
B | 0010467 | biological_process | gene expression |
B | 0010628 | biological_process | positive regulation of gene expression |
B | 0012505 | cellular_component | endomembrane system |
B | 0014009 | biological_process | glial cell proliferation |
B | 0016020 | cellular_component | membrane |
B | 0016601 | biological_process | Rac protein signal transduction |
B | 0016787 | molecular_function | hydrolase activity |
B | 0019003 | molecular_function | GDP binding |
B | 0021897 | biological_process | forebrain astrocyte development |
B | 0030036 | biological_process | actin cytoskeleton organization |
B | 0030857 | biological_process | negative regulation of epithelial cell differentiation |
B | 0032228 | biological_process | regulation of synaptic transmission, GABAergic |
B | 0035022 | biological_process | positive regulation of Rac protein signal transduction |
B | 0035914 | biological_process | skeletal muscle cell differentiation |
B | 0043495 | molecular_function | protein-membrane adaptor activity |
B | 0043524 | biological_process | negative regulation of neuron apoptotic process |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0048169 | biological_process | regulation of long-term neuronal synaptic plasticity |
B | 0048873 | biological_process | homeostasis of number of cells within a tissue |
B | 0051146 | biological_process | striated muscle cell differentiation |
B | 0051402 | biological_process | neuron apoptotic process |
B | 0060252 | biological_process | positive regulation of glial cell proliferation |
B | 0060441 | biological_process | epithelial tube branching involved in lung morphogenesis |
B | 0060509 | biological_process | type I pneumocyte differentiation |
C | 0005576 | cellular_component | extracellular region |
C | 0006869 | biological_process | lipid transport |
C | 0008289 | molecular_function | lipid binding |
C | 0042157 | biological_process | lipoprotein metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 1 |
Chain | Residue |
A | PCW26 |
A | 17F35 |
A | 17F40 |
B | MET1 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 2 |
Chain | Residue |
A | PCW5 |
A | PCW17 |
A | PCW53 |
A | HIS356 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 3 |
Chain | Residue |
A | PCW19 |
A | PCW23 |
A | PCW18 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 4 |
Chain | Residue |
A | PCW7 |
A | PCW16 |
A | 17F33 |
A | PCW61 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 5 |
Chain | Residue |
A | PCW2 |
A | PCW17 |
A | 17F38 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PCW A 6 |
Chain | Residue |
A | PCW7 |
A | PCW16 |
A | PCW24 |
A | PCW28 |
A | 17F39 |
B | GLU3 |
B | ARG41 |
B | ASP54 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 7 |
Chain | Residue |
A | PCW4 |
A | PCW6 |
A | PCW16 |
B | THR2 |
B | GLN43 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 8 |
Chain | Residue |
A | PCW27 |
B | LYS184 |
C | LYS451 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PCW A 9 |
Chain | Residue |
A | PCW14 |
A | PCW25 |
A | PCW26 |
A | PCW28 |
A | PCW30 |
A | 17F34 |
B | GLN70 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PCW A 10 |
Chain | Residue |
A | PCW21 |
A | PCW22 |
A | 17F36 |
B | LYS179 |
B | LYS180 |
B | LYS182 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 11 |
Chain | Residue |
A | PCW24 |
A | PCW25 |
A | PCW67 |
B | GLU37 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 12 |
Chain | Residue |
A | PCW22 |
A | 17F36 |
A | 17F37 |
B | LYS177 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 13 |
Chain | Residue |
A | PCW14 |
A | PCW18 |
A | PCW30 |
A | 17F34 |
A | 17F37 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 14 |
Chain | Residue |
A | PCW9 |
A | PCW13 |
A | 17F34 |
B | GLN70 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 15 |
Chain | Residue |
A | PCW16 |
A | PCW24 |
A | 17F39 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PCW A 16 |
Chain | Residue |
A | PCW4 |
A | PCW6 |
A | PCW7 |
A | PCW15 |
A | 17F39 |
B | ARG41 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 17 |
Chain | Residue |
A | PCW2 |
A | PCW5 |
A | 17F36 |
B | SER171 |
B | LYS172 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 18 |
Chain | Residue |
A | PCW3 |
A | PCW13 |
A | PCW23 |
A | 17F34 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 19 |
Chain | Residue |
A | PCW3 |
A | PCW23 |
A | PCW29 |
site_id | CC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 20 |
Chain | Residue |
A | PCW24 |
A | PCW31 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 21 |
Chain | Residue |
A | PCW10 |
A | 17F36 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PCW A 22 |
Chain | Residue |
A | PCW10 |
A | PCW12 |
A | 17F37 |
B | LYS177 |
B | LYS178 |
B | LYS182 |
B | CYS185 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 23 |
Chain | Residue |
A | PCW29 |
A | PCW3 |
A | PCW18 |
A | PCW19 |
site_id | CC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PCW A 24 |
Chain | Residue |
A | PCW6 |
A | PCW11 |
A | PCW15 |
A | PCW20 |
A | PCW31 |
A | 17F39 |
B | GLU37 |
B | SER39 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 25 |
Chain | Residue |
A | PCW9 |
A | PCW11 |
A | PCW31 |
site_id | CC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 26 |
Chain | Residue |
A | PCW1 |
A | PCW9 |
A | PCW28 |
site_id | CC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PCW A 27 |
Chain | Residue |
A | PCW8 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PCW A 28 |
Chain | Residue |
A | PCW6 |
A | PCW9 |
A | PCW26 |
B | MET1 |
B | GLU3 |
B | LYS5 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 29 |
Chain | Residue |
A | PCW19 |
A | PCW23 |
A | ASP246 |
C | TYR521 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 30 |
Chain | Residue |
A | PCW9 |
A | PCW13 |
A | 17F34 |
A | 17F40 |
B | ASP105 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 31 |
Chain | Residue |
A | PCW20 |
A | PCW24 |
A | PCW25 |
site_id | DC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 32 |
Chain | Residue |
A | 17F33 |
A | 17F35 |
site_id | DC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 17F A 33 |
Chain | Residue |
A | PCW4 |
A | PCW32 |
site_id | DC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 17F A 34 |
Chain | Residue |
A | PCW9 |
A | PCW13 |
A | PCW14 |
A | PCW18 |
A | PCW30 |
site_id | DC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 17F A 35 |
Chain | Residue |
A | PCW1 |
A | PCW32 |
site_id | DC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 17F A 36 |
Chain | Residue |
A | PCW10 |
A | PCW12 |
A | PCW17 |
A | PCW21 |
B | LYS179 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 17F A 37 |
Chain | Residue |
A | PCW12 |
A | PCW13 |
A | PCW22 |
B | LYS177 |
B | LYS178 |
site_id | EC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE 17F A 38 |
Chain | Residue |
A | PCW5 |
site_id | EC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 17F A 39 |
Chain | Residue |
A | PCW6 |
A | PCW15 |
A | PCW16 |
A | PCW24 |
B | ARG41 |
site_id | EC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 17F A 40 |
Chain | Residue |
A | PCW1 |
A | PCW30 |
B | MET170 |
B | LYS175 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 41 |
Chain | Residue |
A | PCW52 |
A | PCW61 |
A | 17F77 |
site_id | EC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 42 |
Chain | Residue |
A | PCW52 |
A | PCW63 |
A | PCW69 |
A | 17F75 |
site_id | EC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 43 |
Chain | Residue |
A | PCW45 |
A | PCW68 |
A | 17F74 |
A | 17F75 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 44 |
Chain | Residue |
A | PCW53 |
A | PCW55 |
A | PCW69 |
A | 17F77 |
site_id | EC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 45 |
Chain | Residue |
A | PCW43 |
A | PCW71 |
site_id | FC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 46 |
Chain | Residue |
A | PCW51 |
A | PCW71 |
site_id | FC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 47 |
Chain | Residue |
A | PCW71 |
A | 17F73 |
A | 17F76 |
site_id | FC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 48 |
Chain | Residue |
A | PCW58 |
A | PCW61 |
site_id | FC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 49 |
Chain | Residue |
A | PCW57 |
A | PCW65 |
A | 17F80 |
site_id | FC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PCW A 50 |
Chain | Residue |
A | 17F78 |
site_id | FC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 51 |
Chain | Residue |
A | PCW46 |
A | PCW56 |
A | PCW71 |
site_id | FC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 52 |
Chain | Residue |
A | PCW41 |
A | PCW42 |
A | PCW60 |
site_id | FC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 53 |
Chain | Residue |
A | PCW2 |
A | PCW44 |
A | PCW55 |
A | PCW64 |
A | PCW68 |
site_id | FC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 54 |
Chain | Residue |
A | PCW62 |
A | PCW72 |
site_id | GC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 55 |
Chain | Residue |
A | PCW44 |
A | PCW53 |
A | PCW64 |
site_id | GC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 56 |
Chain | Residue |
A | PCW51 |
A | PCW70 |
site_id | GC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 57 |
Chain | Residue |
A | PCW49 |
A | 17F80 |
site_id | GC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 58 |
Chain | Residue |
A | PCW48 |
A | PCW61 |
site_id | GC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 59 |
Chain | Residue |
A | PCW61 |
A | 17F77 |
site_id | GC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 60 |
Chain | Residue |
A | PCW52 |
A | PCW63 |
site_id | GC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PCW A 61 |
Chain | Residue |
A | PCW4 |
A | PCW41 |
A | PCW48 |
A | PCW58 |
A | PCW59 |
site_id | GC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 62 |
Chain | Residue |
A | PCW54 |
A | PCW67 |
A | PCW72 |
A | 17F78 |
site_id | GC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 63 |
Chain | Residue |
A | PCW42 |
A | PCW60 |
A | 17F75 |
site_id | HC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 64 |
Chain | Residue |
A | PCW53 |
A | PCW55 |
site_id | HC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 65 |
Chain | Residue |
A | PCW49 |
A | PCW66 |
A | 17F80 |
site_id | HC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 66 |
Chain | Residue |
A | PCW65 |
A | PCW67 |
A | 17F78 |
A | 17F79 |
site_id | HC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 67 |
Chain | Residue |
A | PCW11 |
A | PCW62 |
A | PCW66 |
A | 17F75 |
site_id | HC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 68 |
Chain | Residue |
A | PCW43 |
A | PCW53 |
A | PCW69 |
A | PCW70 |
site_id | HC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PCW A 69 |
Chain | Residue |
A | PCW42 |
A | PCW44 |
A | PCW68 |
site_id | HC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 70 |
Chain | Residue |
A | PCW56 |
A | PCW68 |
site_id | HC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PCW A 71 |
Chain | Residue |
A | PCW45 |
A | PCW46 |
A | PCW47 |
A | PCW51 |
site_id | HC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PCW A 72 |
Chain | Residue |
A | PCW54 |
A | PCW62 |
site_id | IC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 17F A 73 |
Chain | Residue |
A | PCW47 |
A | 17F76 |
site_id | IC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE 17F A 74 |
Chain | Residue |
A | PCW43 |
site_id | IC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 17F A 75 |
Chain | Residue |
A | PCW42 |
A | PCW43 |
A | PCW63 |
A | PCW67 |
A | 17F79 |
site_id | IC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 17F A 76 |
Chain | Residue |
A | PCW47 |
A | 17F73 |
site_id | IC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 17F A 77 |
Chain | Residue |
A | PCW41 |
A | PCW44 |
A | PCW59 |
C | THR592 |
site_id | IC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 17F A 78 |
Chain | Residue |
A | PCW50 |
A | PCW62 |
A | PCW66 |
site_id | IC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 17F A 79 |
Chain | Residue |
A | PCW66 |
A | 17F75 |
site_id | IC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 17F A 80 |
Chain | Residue |
A | PCW49 |
A | PCW57 |
A | PCW65 |
site_id | IC9 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GNP B 201 |
Chain | Residue |
B | GLY13 |
B | VAL14 |
B | GLY15 |
B | LYS16 |
B | SER17 |
B | ALA18 |
B | PHE28 |
B | VAL29 |
B | ASP30 |
B | GLU31 |
B | TYR32 |
B | ASP33 |
B | PRO34 |
B | THR35 |
B | ASN116 |
B | LYS117 |
B | ALA146 |
B | LYS147 |
site_id | JC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 202 |
Chain | Residue |
B | SER17 |
B | THR35 |
B | ASP38 |
B | ASP57 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 |
Chain | Residue | Details |
B | GLY10 | |
B | VAL29 | |
B | ALA59 | |
B | ASN116 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 |
Chain | Residue | Details |
B | MET1 | |
C | LYS594 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 |
Chain | Residue | Details |
B | THR2 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838 |
Chain | Residue | Details |
B | LYS104 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:29239724 |
Chain | Residue | Details |
B | LYS180 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | LIPID: N6-palmitoyl lysine => ECO:0000269|PubMed:29239724 |
Chain | Residue | Details |
B | LYS182 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | LIPID: N6-palmitoyl lysine => ECO:0000305|PubMed:29239724 |
Chain | Residue | Details |
B | LYS184 | |
B | CYS185 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 |
Chain | Residue | Details |
B | THR35 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762 |
Chain | Residue | Details |
B | MET170 |