2MSB

STRUCTURE OF A C-TYPE MANNOSE-BINDING PROTEIN COMPLEXED WITH AN OLIGOSACCHARIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001867	biological_process	complement activation, lectin pathway
A	0005537	molecular_function	mannose binding
B	0001867	biological_process	complement activation, lectin pathway
B	0005537	molecular_function	mannose binding

Functional Information from PDB Data

site_id	C11
Number of Residues	6
Details	calcium binding site

Chain	Residue
A	ASP161
A	GLU165
A	ASP188
A	GLU193
A	ASP194
A	HOH222

---

site_id	C12
Number of Residues	6
Details	calcium binding site

Chain	Residue
B	ASP161
B	GLU165
B	ASP188
B	GLU193
B	ASP194
B	HOH223

---

site_id	C21
Number of Residues	6
Details	calcium binding site

Chain	Residue
A	ASN205
A	ASP206
C	MAN6
A	GLU185
A	ASN187
A	GLU193

---

site_id	C22
Number of Residues	6
Details	calcium binding site

Chain	Residue
B	GLU185
B	ASN187
B	GLU193
B	ASN205
B	ASP206
C	MAN4

---

site_id	C31
Number of Residues	6
Details	calcium binding site

Chain	Residue
A	GLU165
A	ASP194
A	HOH231
A	HOH240
A	HOH241
A	HOH242

---

site_id	C32
Number of Residues	6
Details	calcium binding site

Chain	Residue
B	GLU165
B	ASP194
B	HOH235
B	HOH232
B	HOH233
B	HOH237

---

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	23
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVtivdngl.....WNDISCqasht.AVC

Chain	Residue	Details
A	CYS195-CYS217

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Calcium-dependent carbohydrate binding","evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7704532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2MSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KMB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7704532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2MSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KMB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	95
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---