2MPM

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal Region of CCR3 Bound to CCL11/Eotaxin-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0002544	biological_process	chronic inflammatory response
A	0002551	biological_process	mast cell chemotaxis
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006468	biological_process	protein phosphorylation
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007010	biological_process	cytoskeleton organization
A	0007015	biological_process	actin filament organization
A	0007155	biological_process	cell adhesion
A	0007165	biological_process	signal transduction
A	0007611	biological_process	learning or memory
A	0008009	molecular_function	chemokine activity
A	0008360	biological_process	regulation of cell shape
A	0009314	biological_process	response to radiation
A	0009615	biological_process	response to virus
A	0030335	biological_process	positive regulation of cell migration
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0031728	molecular_function	CCR3 chemokine receptor binding
A	0035962	biological_process	response to interleukin-13
A	0045766	biological_process	positive regulation of angiogenesis
A	0046983	molecular_function	protein dimerization activity
A	0048018	molecular_function	receptor ligand activity
A	0048020	molecular_function	CCR chemokine receptor binding
A	0048245	biological_process	eosinophil chemotaxis
A	0050768	biological_process	negative regulation of neurogenesis
A	0060326	biological_process	cell chemotaxis
A	0060444	biological_process	branching involved in mammary gland duct morphogenesis
A	0060763	biological_process	mammary duct terminal end bud growth
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070670	biological_process	response to interleukin-4

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	43
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFnlanrk..IplqrLesYrritsgk.Cpqk.AVIFktklakdi.CA

Chain	Residue	Details
A	CYS9-ALA51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"9578468","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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