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2MPM

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal Region of CCR3 Bound to CCL11/Eotaxin-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002544biological_processchronic inflammatory response
A0002551biological_processmast cell chemotaxis
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006468biological_processprotein phosphorylation
A0006874biological_processintracellular calcium ion homeostasis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007010biological_processcytoskeleton organization
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007611biological_processlearning or memory
A0008009molecular_functionchemokine activity
A0008360biological_processregulation of cell shape
A0009314biological_processresponse to radiation
A0009615biological_processresponse to virus
A0030335biological_processpositive regulation of cell migration
A0030838biological_processpositive regulation of actin filament polymerization
A0031728molecular_functionCCR3 chemokine receptor binding
A0035962biological_processresponse to interleukin-13
A0043547biological_processpositive regulation of GTPase activity
A0045766biological_processpositive regulation of angiogenesis
A0046983molecular_functionprotein dimerization activity
A0048018molecular_functionreceptor ligand activity
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0050768biological_processnegative regulation of neurogenesis
A0060444biological_processbranching involved in mammary gland duct morphogenesis
A0060763biological_processmammary duct terminal end bud growth
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070371biological_processERK1 and ERK2 cascade
A0070670biological_processresponse to interleukin-4
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues43
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFnlanrk..IplqrLesYrritsgk.Cpqk.AVIFktklakdi.CA
ChainResidueDetails
ACYS9-ALA51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:9578468
ChainResidueDetails
ATHR71

226707

PDB entries from 2024-10-30

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