2MP0
Protein Phosphorylation upon a Fleeting Encounter
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016301 | molecular_function | kinase activity |
| B | 0034763 | biological_process | negative regulation of transmembrane transport |
| B | 0043610 | biological_process | regulation of carbohydrate utilization |
| B | 0045912 | biological_process | negative regulation of carbohydrate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1902344 | biological_process | negative regulation of maltose transport |
| B | 1902495 | cellular_component | transmembrane transporter complex |
| B | 1990154 | cellular_component | enzyme IIA-maltose transporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO3 B 500 |
| Chain | Residue |
| A | HIS189 |
| B | PHE371 |
| B | HIS375 |
| B | HIS390 |
| B | VAL396 |
Functional Information from PROSITE/UniProt
| site_id | PS00370 |
| Number of Residues | 12 |
| Details | PEP_ENZYMES_PHOS_SITE PEP-utilizing enzymes phosphorylation site signature. GGrTsHTSIMAR |
| Chain | Residue | Details |
| A | GLY184-ARG195 |
| site_id | PS00371 |
| Number of Residues | 13 |
| Details | PTS_EIIA_TYPE_1_HIS PTS EIIA domains phosphorylation site signature 1. GveLFVHFGIdTV |
| Chain | Residue | Details |
| B | GLY384-VAL396 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate; for EIIA activity => ECO:0000255|PROSITE-ProRule:PRU00416, ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:6383826, ECO:0000305|PubMed:1961703, ECO:0000305|PubMed:9405042 |
| Chain | Residue | Details |
| B | HIS390 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:9405042, ECO:0000305|PubMed:1961703 |
| Chain | Residue | Details |
| B | HIS375 | |
| B | HIS390 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for phospho-donor activity => ECO:0000269|PubMed:2657735 |
| Chain | Residue | Details |
| B | HIS375 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphohistidine; by HPr => ECO:0000269|PubMed:2657735 |
| Chain | Residue | Details |
| B | HIS390 |
Catalytic Information from CSA
