2M9Q

NMR structure of an inhibitor bound dengue NS3 protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005524	molecular_function	ATP binding
A	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	55
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	SER2-GLY57

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site_id	SWS_FT_FI2
Number of Residues	20
Details	INTRAMEM: Helical => ECO:0000255

Chain	Residue	Details
A	GLY58-GLU78

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site_id	SWS_FT_FI3
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
A	ASP136
A	ALA160
A	GLY220

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
A	ARG85

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