2M6I
Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 105 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | TYR223-ILE244 | |
| B | TYR223-ILE244 | |
| C | TYR223-ILE244 | |
| D | TYR223-ILE244 | |
| E | TYR223-ILE244 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | ASN245-ALA249 | |
| B | ASN245-ALA249 | |
| C | ASN245-ALA249 | |
| D | ASN245-ALA249 | |
| E | ASN245-ALA249 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | PRO250-SER270 | |
| B | PRO250-SER270 | |
| C | PRO250-SER270 | |
| D | PRO250-SER270 | |
| E | PRO250-SER270 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | ARG271-LYS281 | |
| B | ARG271-LYS281 | |
| C | ARG271-LYS281 | |
| D | ARG271-LYS281 | |
| E | ARG271-LYS281 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | ALA282-ALA302 | |
| B | ALA282-ALA302 | |
| C | ALA282-ALA302 | |
| D | ALA282-ALA302 | |
| E | ALA282-ALA302 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 470 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23994010 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:23994010 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:25730860 |
| Chain | Residue | Details |
| A | LEU261 | |
| B | LEU261 | |
| C | LEU261 | |
| D | LEU261 | |
| E | LEU261 |
