2M65

NMR structure of human restriction factor APOBEC3A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0009972	biological_process	cytidine deamination
A	0010526	biological_process	retrotransposon silencing
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0047844	molecular_function	deoxycytidine deaminase activity
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
A	0080111	biological_process	DNA demethylation

Functional Information from PDB Data

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	41
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV

Chain	Residue	Details
A	HIS70-VAL110

Functional Information from SwissProt/UniProt

Chain	Residue	Details
A	GLU72