2LZ3
Solution NMR structure of transmembrane domain of amyloid precursor protein WT
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:22584060, ECO:0000305|PubMed:22654059, ECO:0000305|PubMed:30630874 |
| Chain | Residue | Details |
| A | ILE8-MET28 | |
| B | ILE8-MET28 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY10 | |
| B | GLY10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| A | MET12 | |
| B | MET12 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | VAL17 | |
| B | VAL17 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | ALA19 | |
| B | ALA19 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by gamma-secretase; site 3 => ECO:0000269|PubMed:11851430, ECO:0000305|PubMed:30630874 |
| Chain | Residue | Details |
| A | LEU26 | |
| B | LEU26 |
