2LZ3

Solution NMR structure of transmembrane domain of amyloid precursor protein WT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"22584060","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22654059","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30630874","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"10535332","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by gamma-secretase; site 1","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Cleavage; by gamma-secretase; site 2","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Cleavage; by gamma-secretase; site 3","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30630874","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---