2LXP
NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| A | 0032446 | biological_process | protein modification by small protein conjugation |
| A | 0035458 | biological_process | cellular response to interferon-beta |
| A | 0036503 | biological_process | ERAD pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 1904153 | biological_process | negative regulation of retrograde protein transport, ER to cytosol |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 900 |
| Chain | Residue |
| C | CYS341 |
| C | CYS344 |
| C | HIS361 |
| C | CYS364 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 901 |
| Chain | Residue |
| C | CYS356 |
| C | HIS358 |
| C | CYS375 |
| C | CYS378 |
Functional Information from PROSITE/UniProt
| site_id | PS00183 |
| Number of Residues | 16 |
| Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNIypd.GrVCIsiL |
| Chain | Residue | Details |
| A | PHE78-LEU93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| C | CYS341-ARG379 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 |
