2LUX
Calcium saturated form of human C85M S100A1 mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0008016 | biological_process | regulation of heart contraction |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042311 | biological_process | vasodilation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044548 | molecular_function | S100 protein binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0051117 | molecular_function | ATPase binding |
| A | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0008016 | biological_process | regulation of heart contraction |
| B | 0016529 | cellular_component | sarcoplasmic reticulum |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042311 | biological_process | vasodilation |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044548 | molecular_function | S100 protein binding |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0051117 | molecular_function | ATPase binding |
| B | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 201 |
| Chain | Residue |
| A | SER19 |
| A | GLU22 |
| A | GLY23 |
| A | ASP24 |
| A | LYS27 |
| A | GLU32 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 202 |
| Chain | Residue |
| A | GLU68 |
| A | GLU73 |
| A | ASP62 |
| A | ASN64 |
| A | ASP66 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 101 |
| Chain | Residue |
| B | SER19 |
| B | GLU22 |
| B | GLY23 |
| B | ASP24 |
| B | LYS27 |
| B | GLU32 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 102 |
| Chain | Residue |
| B | ASP62 |
| B | ASN64 |
| B | ASP66 |
| B | GLU68 |
| B | GLU73 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"22989881","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
