2LQN

Solution structure of CRKL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007167	biological_process	enzyme-linked receptor protein signaling pathway
A	0007254	biological_process	JNK cascade
A	0007265	biological_process	Ras protein signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010468	biological_process	regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0016477	biological_process	cell migration
A	0030334	biological_process	regulation of cell migration
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031594	cellular_component	neuromuscular junction
A	0032991	cellular_component	protein-containing complex
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0035556	biological_process	intracellular signal transduction
A	0035591	molecular_function	signaling adaptor activity
A	0042802	molecular_function	identical protein binding
A	0045202	cellular_component	synapse
A	0045296	molecular_function	cadherin binding
A	0060392	biological_process	negative regulation of SMAD protein signal transduction
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071363	biological_process	cellular response to growth factor stimulus
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	0098698	biological_process	postsynaptic specialization assembly
A	0098890	cellular_component	extrinsic component of postsynaptic membrane
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1903977	biological_process	positive regulation of glial cell migration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Domain: {"description":"SH3 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	61
Details	Domain: {"description":"SH3 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	50
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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