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2LM5

Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002931biological_processresponse to ischemia
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006302biological_processdouble-strand break repair
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007026biological_processnegative regulation of microtubule depolymerization
A0007049biological_processcell cycle
A0007113biological_processendomitotic cell cycle
A0007155biological_processcell adhesion
A0007283biological_processspermatogenesis
A0007286biological_processspermatid development
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030027cellular_componentlamellipodium
A0030154biological_processcell differentiation
A0030220biological_processplatelet formation
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0031122biological_processcytoplasmic microtubule organization
A0031267molecular_functionsmall GTPase binding
A0031982cellular_componentvesicle
A0032433cellular_componentfilopodium tip
A0032587cellular_componentruffle membrane
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0038163biological_processthrombopoietin-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043085biological_processpositive regulation of catalytic activity
A0043204cellular_componentperikaryon
A0043495molecular_functionprotein-membrane adaptor activity
A0044325molecular_functiontransmembrane transporter binding
A0045653biological_processnegative regulation of megakaryocyte differentiation
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051301biological_processcell division
A0051302biological_processregulation of cell division
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0090314biological_processpositive regulation of protein targeting to membrane
A0097191biological_processextrinsic apoptotic signaling pathway
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1990090biological_processcellular response to nerve growth factor stimulus
A2000256biological_processpositive regulation of male germ cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 500
ChainResidue
AASP116
AASP118
AASP120
ATHR122
AASN124
AASP127

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 501
ChainResidue
ATHR167
AGLU172
AASP161
AASP163
AASP165

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DFDDDGTLNreDL
ChainResidueDetails
AASP116-LEU128
AASP161-PHE173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP116
AGLU172
AASP118
AASP120
ATHR122
AASP127
AASP161
AASP163
AASP165
ATHR167

site_idSWS_FT_FI2
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:10366599
ChainResidueDetails
AGLY2

218853

PDB entries from 2024-04-24

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