2LLU

Post-translational S-nitrosylation is an endogenous factor fine-tuning human S100A1 protein properties

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0008016	biological_process	regulation of heart contraction
A	0016529	cellular_component	sarcoplasmic reticulum
A	0021762	biological_process	substantia nigra development
A	0030018	cellular_component	Z disc
A	0031430	cellular_component	M band
A	0031672	cellular_component	A band
A	0031674	cellular_component	I band
A	0032991	cellular_component	protein-containing complex
A	0035556	biological_process	intracellular signal transduction
A	0042311	biological_process	vasodilation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044548	molecular_function	S100 protein binding
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0051117	molecular_function	ATPase binding
A	1903672	biological_process	positive regulation of sprouting angiogenesis
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0008016	biological_process	regulation of heart contraction
B	0016529	cellular_component	sarcoplasmic reticulum
B	0021762	biological_process	substantia nigra development
B	0030018	cellular_component	Z disc
B	0031430	cellular_component	M band
B	0031672	cellular_component	A band
B	0031674	cellular_component	I band
B	0032991	cellular_component	protein-containing complex
B	0035556	biological_process	intracellular signal transduction
B	0042311	biological_process	vasodilation
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044548	molecular_function	S100 protein binding
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0051117	molecular_function	ATPase binding
B	1903672	biological_process	positive regulation of sprouting angiogenesis

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENGDGEVDfqEY

Chain	Residue	Details
A	ASP62-TYR74

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. VMkeLDengDgevDFqEYvvLV

Chain	Residue	Details
A	VAL57-VAL78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"22989881","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---