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2LLS

solution structure of human apo-S100A1 C85M

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0008016biological_processregulation of heart contraction
A0016529cellular_componentsarcoplasmic reticulum
A0021762biological_processsubstantia nigra development
A0030018cellular_componentZ disc
A0031430cellular_componentM band
A0031672cellular_componentA band
A0031674cellular_componentI band
A0032991cellular_componentprotein-containing complex
A0035556biological_processintracellular signal transduction
A0042311biological_processvasodilation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0044548molecular_functionS100 protein binding
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0051117molecular_functionATPase binding
A1903672biological_processpositive regulation of sprouting angiogenesis
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0008016biological_processregulation of heart contraction
B0016529cellular_componentsarcoplasmic reticulum
B0021762biological_processsubstantia nigra development
B0030018cellular_componentZ disc
B0031430cellular_componentM band
B0031672cellular_componentA band
B0031674cellular_componentI band
B0032991cellular_componentprotein-containing complex
B0035556biological_processintracellular signal transduction
B0042311biological_processvasodilation
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0044548molecular_functionS100 protein binding
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0051117molecular_functionATPase binding
B1903672biological_processpositive regulation of sprouting angiogenesis
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DENGDGEVDfqEY
ChainResidueDetails
AASP62-TYR74

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. VMkeLDengDgevDFqEYvvLV
ChainResidueDetails
AVAL57-VAL78

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:23351007, ECO:0000269|PubMed:28368280
ChainResidueDetails
ALYS27
AGLU32
BLYS27
BGLU32

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23351007, ECO:0000269|PubMed:28368280
ChainResidueDetails
AASP62
BGLU73
AASN64
AASP66
AGLU68
AGLU73
BASP62
BASN64
BASP66
BGLU68

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:22989881
ChainResidueDetails
AMET85
BMET85

237423

PDB entries from 2025-06-11

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