2LGV

Rbx1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000165	biological_process	MAPK cascade
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006974	biological_process	DNA damage response
A	0007283	biological_process	spermatogenesis
A	0007346	biological_process	regulation of mitotic cell cycle
A	0008270	molecular_function	zinc ion binding
A	0008283	biological_process	cell population proliferation
A	0010506	biological_process	regulation of autophagy
A	0010564	biological_process	regulation of cell cycle process
A	0010824	biological_process	regulation of centrosome duplication
A	0014033	biological_process	neural crest cell differentiation
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019788	molecular_function	NEDD8 transferase activity
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030510	biological_process	regulation of BMP signaling pathway
A	0030891	cellular_component	VCB complex
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031297	biological_process	replication fork processing
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032006	biological_process	regulation of TOR signaling
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032480	biological_process	negative regulation of type I interferon production
A	0032814	biological_process	regulation of natural killer cell activation
A	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0034644	biological_process	cellular response to UV
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042110	biological_process	T cell activation
A	0042127	biological_process	regulation of cell population proliferation
A	0042752	biological_process	regulation of circadian rhythm
A	0042770	biological_process	signal transduction in response to DNA damage
A	0042981	biological_process	regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043687	biological_process	post-translational protein modification
A	0044314	biological_process	protein K27-linked ubiquitination
A	0044877	molecular_function	protein-containing complex binding
A	0045116	biological_process	protein neddylation
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045995	biological_process	regulation of embryonic development
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0046872	molecular_function	metal ion binding
A	0050727	biological_process	regulation of inflammatory response
A	0051298	biological_process	centrosome duplication
A	0051726	biological_process	regulation of cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0060173	biological_process	limb development
A	0060271	biological_process	cilium assembly
A	0060964	biological_process	regulation of miRNA-mediated gene silencing
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061663	molecular_function	NEDD8 ligase activity
A	0062197	biological_process	cellular response to chemical stress
A	0070936	biological_process	protein K48-linked ubiquitination
A	0071230	biological_process	cellular response to amino acid stimulus
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0080135	biological_process	regulation of cellular response to stress
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0090734	cellular_component	site of DNA damage
A	0097602	molecular_function	cullin family protein binding
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
A	0160276	biological_process	negative regulation of beige fat cell differentiation
A	1900076	biological_process	regulation of cellular response to insulin stimulus
A	1901524	biological_process	regulation of mitophagy
A	1901525	biological_process	negative regulation of mitophagy
A	1901987	biological_process	regulation of cell cycle phase transition
A	1902412	biological_process	regulation of mitotic cytokinesis
A	1902499	biological_process	positive regulation of protein autoubiquitination
A	1902883	biological_process	negative regulation of response to oxidative stress
A	1904178	biological_process	negative regulation of adipose tissue development
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1904415	biological_process	regulation of xenophagy
A	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
A	2000001	biological_process	regulation of DNA damage checkpoint
A	2000036	biological_process	regulation of stem cell population maintenance
A	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 109

Chain	Residue
A	CYS42
A	CYS45
A	HIS80
A	CYS83

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 110

Chain	Residue
A	CYS53
A	CYS56
A	CYS68
A	HIS82

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 111

Chain	Residue
A	HIS77
A	CYS94
A	ASP97
A	CYS75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---