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2LE9

RAGEC2-S100A13 tetrameric complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0001819biological_processpositive regulation of cytokine production
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008289molecular_functionlipid binding
B0015031biological_processprotein transport
B0017134molecular_functionfibroblast growth factor binding
B0032730biological_processpositive regulation of interleukin-1 alpha production
B0042803molecular_functionprotein homodimerization activity
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043303biological_processmast cell degranulation
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050786molecular_functionRAGE receptor binding
C0001819biological_processpositive regulation of cytokine production
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0008270molecular_functionzinc ion binding
C0008284biological_processpositive regulation of cell population proliferation
C0008289molecular_functionlipid binding
C0015031biological_processprotein transport
C0017134molecular_functionfibroblast growth factor binding
C0032730biological_processpositive regulation of interleukin-1 alpha production
C0042803molecular_functionprotein homodimerization activity
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043303biological_processmast cell degranulation
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050786molecular_functionRAGE receptor binding
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCVATH
ChainResidueDetails
ATYR69-HIS75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
BSER32
CASP64
CASN66
CASP68
CGLU70
CGLU75
BGLU37
BASP64
BASN66
BASP68
BGLU70
BGLU75
CSER32
CGLU37

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97352
ChainResidueDetails
BSER32
CSER32

226707

PDB entries from 2024-10-30

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