2LDR

Solution structure of Helix-RING domain of Cbl-b in the Tyr363 phosphorylated form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1373

Chain	Residue
A	CYS373
A	CYS376
A	ASN379
A	CYS393
A	CYS396

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1388

Chain	Residue
A	CYS411
A	CYS388
A	HIS390
A	CYS408
A	PHE410

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Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS388-LEU397

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
A	CYS373-ARG412

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:20525694

Chain	Residue	Details
A	PTR363

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