Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2LCK

Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment replacement

Functional Information from GO Data
ChainGOidnamespacecontents
A0000266biological_processmitochondrial fission
A0000303biological_processresponse to superoxide
A0001666biological_processresponse to hypoxia
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006096biological_processglycolytic process
A0006541biological_processglutamine metabolic process
A0006839biological_processmitochondrial transport
A0008271molecular_functionsecondary active sulfate transmembrane transporter activity
A0009409biological_processresponse to cold
A0009749biological_processresponse to glucose
A0015078molecular_functionproton transmembrane transporter activity
A0015108molecular_functionchloride transmembrane transporter activity
A0015131molecular_functionoxaloacetate transmembrane transporter activity
A0015140molecular_functionmalate transmembrane transporter activity
A0015183molecular_functionL-aspartate transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015740biological_processC4-dicarboxylate transport
A0015909biological_processlong-chain fatty acid transport
A0016020cellular_componentmembrane
A0017077molecular_functionoxidative phosphorylation uncoupler activity
A0019003molecular_functionGDP binding
A0030225biological_processmacrophage differentiation
A0031966cellular_componentmitochondrial membrane
A0032869biological_processcellular response to insulin stimulus
A0032870biological_processcellular response to hormone stimulus
A0034198biological_processcellular response to amino acid starvation
A0035435biological_processphosphate ion transmembrane transport
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0051881biological_processregulation of mitochondrial membrane potential
A0055085biological_processtransmembrane transport
A0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
A0070542biological_processresponse to fatty acid
A0070778biological_processL-aspartate transmembrane transport
A0071284biological_processcellular response to lead ion
A0071333biological_processcellular response to glucose stimulus
A0071423biological_processmalate transmembrane transport
A0071548biological_processresponse to dexamethasone
A0072593biological_processreactive oxygen species metabolic process
A0097421biological_processliver regeneration
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140787molecular_functionphosphate ion uniporter activity
A1902356biological_processoxaloacetate(2-) transmembrane transport
A1902358biological_processsulfate transmembrane transport
A1902476biological_processchloride transmembrane transport
A1902600biological_processproton transmembrane transport
A1990542biological_processmitochondrial transmembrane transport
A1990845biological_processadaptive thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues23
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
APHE17-ARG40

site_idSWS_FT_FI2
Number of Residues88
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000305
ChainResidueDetails
ALEU41-SER77
AALA146-ARG173
AMET243-ALA268

site_idSWS_FT_FI3
Number of Residues25
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
ALEU78-VAL103

site_idSWS_FT_FI4
Number of Residues46
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000305
ChainResidueDetails
ALYS104-ARG119
AILE200-HIS217
ALYS295-PHE309

site_idSWS_FT_FI5
Number of Residues25
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
ALEU120-GLN145

site_idSWS_FT_FI6
Number of Residues25
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
AGLY174-LEU199

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
APHE218-TYR242

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:21785437, ECO:0007744|PDB:2LCK
ChainResidueDetails
APHE269-LEU294

site_idSWS_FT_FI9
Number of Residues2
DetailsSITE: Important for inhibition by GDP => ECO:0000269|PubMed:25127353
ChainResidueDetails
ALYS141
AARG185

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon