2LCK
Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment replacement
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000266 | biological_process | mitochondrial fission |
| A | 0000303 | biological_process | response to superoxide |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008271 | molecular_function | secondary active sulfate transmembrane transporter activity |
| A | 0009409 | biological_process | response to cold |
| A | 0009749 | biological_process | response to glucose |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015131 | molecular_function | oxaloacetate transmembrane transporter activity |
| A | 0015140 | molecular_function | malate transmembrane transporter activity |
| A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015740 | biological_process | C4-dicarboxylate transport |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0017077 | molecular_function | oxidative phosphorylation uncoupler activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0030225 | biological_process | macrophage differentiation |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0032870 | biological_process | cellular response to hormone stimulus |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043524 | biological_process | negative regulation of neuron apoptotic process |
| A | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0061179 | biological_process | negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0070542 | biological_process | response to fatty acid |
| A | 0070778 | biological_process | L-aspartate transmembrane transport |
| A | 0071284 | biological_process | cellular response to lead ion |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071423 | biological_process | malate transmembrane transport |
| A | 0071548 | biological_process | response to dexamethasone |
| A | 0072593 | biological_process | reactive oxygen species metabolic process |
| A | 0097421 | biological_process | liver regeneration |
| A | 0110099 | biological_process | negative regulation of calcium import into the mitochondrion |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 0140787 | molecular_function | phosphate ion uniporter activity |
| A | 1902356 | biological_process | oxaloacetate(2-) transmembrane transport |
| A | 1902358 | biological_process | sulfate transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990542 | biological_process | mitochondrial transmembrane transport |
| A | 1990845 | biological_process | adaptive thermogenesis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"21785437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LCK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 89 |
| Details | Repeat: {"description":"Solcar 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00282","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 85 |
| Details | Repeat: {"description":"Solcar 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00282","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 54 |
| Details | Region: {"description":"Important for interaction with long-chain fatty acids","evidences":[{"source":"PubMed","id":"25127353","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for inhibition by GDP","evidences":[{"source":"PubMed","id":"25127353","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
