2L31
Human PARP-1 zinc finger 2
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 215 |
| Chain | Residue |
| A | CYS125 |
| A | CYS128 |
| A | HIS159 |
| A | CYS162 |
Functional Information from PROSITE/UniProt
| site_id | PS00347 |
| Number of Residues | 38 |
| Details | ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKgCmekIeKgqvRlskkmvdpekpqlgmidrWYHpgC |
| Chain | Residue | Details |
| A | CYS125-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | ZN_FING: PARP-type 2 => ECO:0000255|PROSITE-ProRule:PRU00264 |
| Chain | Residue | Details |
| A | PHE113-LYS203 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00264, ECO:0000269|PubMed:21233213, ECO:0000269|PubMed:22683995, ECO:0007744|PDB:3ODC, ECO:0007744|PDB:3ODE, ECO:0007744|PDB:4AV1 |
| Chain | Residue | Details |
| A | CYS125 | |
| A | CYS128 | |
| A | HIS159 | |
| A | CYS162 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase-3 and caspase-7 => ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:7596430 |
| Chain | Residue | Details |
| A | ASP214 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS105 | |
| A | LYS131 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER177 | |
| A | SER185 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER179 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS192 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS203 |
