2L0X

Solution structure of the 21 kDa GTPase RHEB bound to GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005681	cellular_component	spliceosomal complex
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0009615	biological_process	response to virus
A	0012505	cellular_component	endomembrane system
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0030295	molecular_function	protein kinase activator activity
A	0030425	cellular_component	dendrite
A	0031669	biological_process	cellular response to nutrient levels
A	0032006	biological_process	regulation of TOR signaling
A	0032008	biological_process	positive regulation of TOR signaling
A	0043025	cellular_component	neuronal cell body
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0048168	biological_process	regulation of neuronal synaptic plasticity
A	0048709	biological_process	oligodendrocyte differentiation
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
A	1904263	biological_process	positive regulation of TORC1 signaling
A	2000074	biological_process	regulation of type B pancreatic cell development

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 185

Chain	Residue
A	SER20
A	THR38
A	GDP186

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP A 186

Chain	Residue
A	SER21
A	PRO37
A	THR38
A	ASN119
A	LYS120
A	ASP122
A	LEU123
A	SER149
A	ALA150
A	LYS151
A	MG185
A	TYR14
A	SER16
A	VAL17
A	GLY18
A	LYS19
A	SER20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20685651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2L0X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for autoinhibition of GTPase activity","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK5","evidences":[{"source":"UniProtKB","id":"Q921J2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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