2L0X
Solution structure of the 21 kDa GTPase RHEB bound to GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0009615 | biological_process | response to virus |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030295 | molecular_function | protein kinase activator activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0031669 | biological_process | cellular response to nutrient levels |
| A | 0032006 | biological_process | regulation of TOR signaling |
| A | 0032008 | biological_process | positive regulation of TOR signaling |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048168 | biological_process | regulation of neuronal synaptic plasticity |
| A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099175 | biological_process | regulation of postsynapse organization |
| A | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| A | 2000074 | biological_process | regulation of type B pancreatic cell development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 185 |
| Chain | Residue |
| A | SER20 |
| A | THR38 |
| A | GDP186 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDP A 186 |
| Chain | Residue |
| A | SER21 |
| A | PRO37 |
| A | THR38 |
| A | ASN119 |
| A | LYS120 |
| A | ASP122 |
| A | LEU123 |
| A | SER149 |
| A | ALA150 |
| A | LYS151 |
| A | MG185 |
| A | TYR14 |
| A | SER16 |
| A | VAL17 |
| A | GLY18 |
| A | LYS19 |
| A | SER20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20685651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2L0X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for autoinhibition of GTPase activity","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPKAPK5","evidences":[{"source":"UniProtKB","id":"Q921J2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
