2L0R

Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV

Chain	Residue	Details
A	GLY13-VAL22

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19651869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9573135","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718924","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718925","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15911756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22342144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25372673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26492514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26578066","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J7N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DV8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 641

Chain	Residue	Details
A	HIS16	metal ligand
A	GLU17	proton acceptor, proton donor
A	HIS20	metal ligand
A	TYR58	electrostatic stabiliser
A	GLU65	metal ligand

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