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2KZ1

Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY

Replaces:  2KSX
Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002286biological_processT cell activation involved in immune response
A0002323biological_processnatural killer cell activation involved in immune response
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005132molecular_functiontype I interferon receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006915biological_processapoptotic process
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0006959biological_processhumoral immune response
A0007166biological_processcell surface receptor signaling pathway
A0007267biological_processcell-cell signaling
A0010629biological_processnegative regulation of gene expression
A0019221biological_processcytokine-mediated signaling pathway
A0030183biological_processB cell differentiation
A0032696biological_processnegative regulation of interleukin-13 production
A0032714biological_processnegative regulation of interleukin-5 production
A0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
A0042100biological_processB cell proliferation
A0043330biological_processresponse to exogenous dsRNA
A0045581biological_processnegative regulation of T cell differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0046597biological_processnegative regulation of viral entry into host cell
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0062023cellular_componentcollagen-containing extracellular matrix
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A2000552biological_processnegative regulation of T-helper 2 cell cytokine production
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW
ChainResidueDetails
ATYR122-TRP140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN31
BASN89
BASN161

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8181059
ChainResidueDetails
BASN60
BASN165

218853

PDB entries from 2024-04-24

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