2KYU

The solution structure of the PHD3 finger of MLL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
A	0071339	cellular_component	MLL1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 81

Chain	Residue
A	CYS8
A	CYS11
A	ASP12
A	HIS35
A	CYS38

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 82

Chain	Residue
A	CYS63
A	CYS27
A	LYS29
A	CYS30
A	CYS60

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	56
Details	ZF_PHD_1 Zinc finger PHD-type signature. CplCdkcyddddyeskm................................MqCgk..Cdrw.VHskCenlsdemyeilsnlpesva..........................YtCvnC

Chain	Residue	Details
A	CYS8-CYS63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	61
Details	Zinc finger: {"description":"PHD-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Interaction with histone H3K4me3","evidences":[{"source":"PubMed","id":"20677832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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