2KUL

Solution structure of human vaccinia related kinase 1(VRK1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005795	cellular_component	Golgi stack
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0007077	biological_process	mitotic nuclear membrane disassembly
A	0007165	biological_process	signal transduction
A	0015030	cellular_component	Cajal body
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019901	molecular_function	protein kinase binding
A	0030576	biological_process	Cajal body organization
A	0031175	biological_process	neuron projection development
A	0031492	molecular_function	nucleosomal DNA binding
A	0035175	molecular_function	histone H3S10 kinase activity
A	0042393	molecular_function	histone binding
A	0046777	biological_process	protein autophosphorylation
A	0051301	biological_process	cell division
A	0072354	molecular_function	histone H3T3 kinase activity
A	0090166	biological_process	Golgi disassembly
A	0106310	molecular_function	protein serine kinase activity
A	0120187	biological_process	positive regulation of protein localization to chromatin
A	0141003	molecular_function	histone H2AX kinase activity
A	2001222	biological_process	regulation of neuron migration

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGGFGCIYlAdmnssesvgsdap.....CVVK

Chain	Residue	Details
A	ILE43-LYS71

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHgDIKasNLLL

Chain	Residue	Details
A	TYR173-LEU185

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP177

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE43
A	LYS71

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:19103756, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER342

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11883897

Chain	Residue	Details
A	THR355

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS71

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