2KTY
Solution Structure of human Vaccinia Related Kinase-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000785 | cellular_component | chromatin |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005795 | cellular_component | Golgi stack |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007077 | biological_process | mitotic nuclear membrane disassembly |
| A | 0007165 | biological_process | signal transduction |
| A | 0015030 | cellular_component | Cajal body |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030576 | biological_process | Cajal body organization |
| A | 0031175 | biological_process | neuron projection development |
| A | 0031492 | molecular_function | nucleosomal DNA binding |
| A | 0035175 | molecular_function | histone H3S10 kinase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0046777 | biological_process | protein autophosphorylation |
| A | 0051301 | biological_process | cell division |
| A | 0072354 | molecular_function | histone H3T3 kinase activity |
| A | 0090166 | biological_process | Golgi disassembly |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0120187 | biological_process | positive regulation of protein localization to chromatin |
| A | 0141003 | molecular_function | histone H2AX kinase activity |
| A | 2001222 | biological_process | regulation of neuron migration |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGGFGCIYlAdmnssesvgsdap.....CVVK |
| Chain | Residue | Details |
| A | ILE43-LYS71 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHgDIKasNLLL |
| Chain | Residue | Details |
| A | TYR173-LEU185 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 280 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PLK3","evidences":[{"source":"PubMed","id":"19103756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"11883897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
