2KT0

Solution structure of human stem cell transcription factor Nanog homeodomain fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LSniLnLSykQVKTWFqNqrmksK

Chain	Residue	Details
A	LEU55-LYS78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	DNA binding: {"description":"Homeobox","evidences":[{"source":"PROSITE-ProRule","id":"PRU00108","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	29
Details	Region: {"description":"Required for DNA-binding","evidences":[{"source":"PubMed","id":"25825768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	9
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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