2KOG
lipid-bound synaptobrevin solution NMR structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000149 | molecular_function | SNARE binding |
| A | 0005484 | molecular_function | SNAP receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006906 | biological_process | vesicle fusion |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009749 | biological_process | response to glucose |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0016079 | biological_process | synaptic vesicle exocytosis |
| A | 0016081 | biological_process | synaptic vesicle docking |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0017022 | molecular_function | myosin binding |
| A | 0017075 | molecular_function | syntaxin-1 binding |
| A | 0017157 | biological_process | regulation of exocytosis |
| A | 0030136 | cellular_component | clathrin-coated vesicle |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031201 | cellular_component | SNARE complex |
| A | 0035493 | biological_process | SNARE complex assembly |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043195 | cellular_component | terminal bouton |
| A | 0044306 | cellular_component | neuron projection terminus |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048488 | biological_process | synaptic vesicle endocytosis |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0070032 | cellular_component | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| A | 0070033 | cellular_component | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| A | 0070044 | cellular_component | synaptobrevin 2-SNAP-25-syntaxin-1a complex |
| A | 0070723 | biological_process | response to cholesterol |
| A | 0072583 | biological_process | clathrin-dependent endocytosis |
| A | 0099524 | cellular_component | postsynaptic cytosol |
| A | 1902259 | biological_process | regulation of delayed rectifier potassium channel activity |
| A | 1903421 | biological_process | regulation of synaptic vesicle recycling |
Functional Information from PROSITE/UniProt
| site_id | PS00417 |
| Number of Residues | 20 |
| Details | SYNAPTOBREVIN Synaptobrevin signature. NVDKVlERdqKLSeLdDRAD |
| Chain | Residue | Details |
| A | ASN49-ASP68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Anchor for type IV membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Topological domain: {"description":"Vesicular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | Domain: {"description":"v-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00290","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Region: {"description":"Required for interaction with SEPT8","evidences":[{"source":"PubMed","id":"19196426","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)","evidences":[{"source":"PubMed","id":"8505288","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)","evidences":[{"source":"PubMed","id":"8175689","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)","evidences":[{"source":"PubMed","id":"28770820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX)","evidences":[{"source":"PubMed","id":"1331807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG)","evidences":[{"source":"PubMed","id":"7910017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"P63026","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
