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2KN6

Structure of full-length human ASC (Apoptosis-associated speck-like protein containing a CARD)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001773biological_processmyeloid dendritic cell activation
A0002020molecular_functionprotease binding
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002277biological_processmyeloid dendritic cell activation involved in immune response
A0002376biological_processimmune system process
A0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
A0002821biological_processpositive regulation of adaptive immune response
A0005138molecular_functioninterleukin-6 receptor binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007231biological_processosmosensory signaling pathway
A0008385cellular_componentIkappaB kinase complex
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0017024molecular_functionmyosin I binding
A0019899molecular_functionenzyme binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030838biological_processpositive regulation of actin filament polymerization
A0031647biological_processregulation of protein stability
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032090molecular_functionPyrin domain binding
A0032688biological_processnegative regulation of interferon-beta production
A0032722biological_processpositive regulation of chemokine production
A0032729biological_processpositive regulation of type II interferon production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032733biological_processpositive regulation of interleukin-10 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032991cellular_componentprotein-containing complex
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035578cellular_componentazurophil granule lumen
A0038187molecular_functionpattern recognition receptor activity
A0042104biological_processpositive regulation of activated T cell proliferation
A0042742biological_processdefense response to bacterium
A0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0044351biological_processmacropinocytosis
A0044546biological_processNLRP3 inflammasome complex assembly
A0045087biological_processinnate immune response
A0046330biological_processpositive regulation of JNK cascade
A0046456biological_processicosanoid biosynthetic process
A0046983molecular_functionprotein dimerization activity
A0050727biological_processregulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0050829biological_processdefense response to Gram-negative bacterium
A0050870biological_processpositive regulation of T cell activation
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051260biological_processprotein homooligomerization
A0051607biological_processdefense response to virus
A0061702cellular_componentcanonical inflammasome complex
A0070269biological_processpyroptotic inflammatory response
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070700molecular_functionBMP receptor binding
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071901biological_processnegative regulation of protein serine/threonine kinase activity
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0072558cellular_componentNLRP1 inflammasome complex
A0072559cellular_componentNLRP3 inflammasome complex
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0097169cellular_componentAIM2 inflammasome complex
A0097190biological_processapoptotic signaling pathway
A0097193biological_processintrinsic apoptotic signaling pathway
A0140608molecular_functioncysteine-type endopeptidase activator activity
A0140632biological_processcanonical inflammasome complex assembly
A0140738cellular_componentNLRP6 inflammasome complex
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A2000406biological_processpositive regulation of T cell migration
A2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
A2001242biological_processregulation of intrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsDomain: {"description":"Pyrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00061","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues88
DetailsDomain: {"description":"CARD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00046","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9EPB4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34706239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25847972","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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