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2KLR

Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001666biological_processresponse to hypoxia
A0002088biological_processlens development in camera-type eye
A0005198molecular_functionstructural molecule activity
A0005212molecular_functionstructural constituent of eye lens
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006457biological_processprotein folding
A0006936biological_processmuscle contraction
A0007021biological_processtubulin complex assembly
A0007517biological_processmuscle organ development
A0008017molecular_functionmicrotubule binding
A0008092molecular_functioncytoskeletal protein binding
A0009408biological_processresponse to heat
A0009892biological_processnegative regulation of metabolic process
A0009986cellular_componentcell surface
A0010629biological_processnegative regulation of gene expression
A0030018cellular_componentZ disc
A0030308biological_processnegative regulation of cell growth
A0030424cellular_componentaxon
A0031109biological_processmicrotubule polymerization or depolymerization
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031430cellular_componentM band
A0031674cellular_componentI band
A0032355biological_processresponse to estradiol
A0032387biological_processnegative regulation of intracellular transport
A0032432cellular_componentactin filament bundle
A0032991cellular_componentprotein-containing complex
A0042026biological_processprotein refolding
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043010biological_processcamera-type eye development
A0043066biological_processnegative regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043292cellular_componentcontractile muscle fiber
A0044877molecular_functionprotein-containing complex binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0050821biological_processprotein stabilization
A0051082molecular_functionunfolded protein binding
A0051403biological_processstress-activated MAPK cascade
A0060561biological_processapoptotic process involved in morphogenesis
A0070062cellular_componentextracellular exosome
A0071480biological_processcellular response to gamma radiation
A0097060cellular_componentsynaptic membrane
A0097512cellular_componentcardiac myofibril
A1905907biological_processnegative regulation of amyloid fibril formation
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0001540molecular_functionamyloid-beta binding
B0001666biological_processresponse to hypoxia
B0002088biological_processlens development in camera-type eye
B0005198molecular_functionstructural molecule activity
B0005212molecular_functionstructural constituent of eye lens
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006457biological_processprotein folding
B0006936biological_processmuscle contraction
B0007021biological_processtubulin complex assembly
B0007517biological_processmuscle organ development
B0008017molecular_functionmicrotubule binding
B0008092molecular_functioncytoskeletal protein binding
B0009408biological_processresponse to heat
B0009892biological_processnegative regulation of metabolic process
B0009986cellular_componentcell surface
B0010629biological_processnegative regulation of gene expression
B0030018cellular_componentZ disc
B0030308biological_processnegative regulation of cell growth
B0030424cellular_componentaxon
B0031109biological_processmicrotubule polymerization or depolymerization
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031430cellular_componentM band
B0031674cellular_componentI band
B0032355biological_processresponse to estradiol
B0032387biological_processnegative regulation of intracellular transport
B0032432cellular_componentactin filament bundle
B0032991cellular_componentprotein-containing complex
B0042026biological_processprotein refolding
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043010biological_processcamera-type eye development
B0043066biological_processnegative regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0043292cellular_componentcontractile muscle fiber
B0044877molecular_functionprotein-containing complex binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0046872molecular_functionmetal ion binding
B0050821biological_processprotein stabilization
B0051082molecular_functionunfolded protein binding
B0051403biological_processstress-activated MAPK cascade
B0060561biological_processapoptotic process involved in morphogenesis
B0070062cellular_componentextracellular exosome
B0071480biological_processcellular response to gamma radiation
B0097060cellular_componentsynaptic membrane
B0097512cellular_componentcardiac myofibril
B1905907biological_processnegative regulation of amyloid fibril formation
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS83
AGLU106
BHIS83
BGLU106

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:22890888
ChainResidueDetails
AHIS104
AHIS111
AHIS119
BHIS104
BHIS111
BHIS119

site_idSWS_FT_FI3
Number of Residues6
DetailsSITE: Susceptible to oxidation
ChainResidueDetails
ATYR48
ATRP60
AMET68
BTYR48
BTRP60
BMET68

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:8142454, ECO:0000269|PubMed:838078
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:8175657
ChainResidueDetails
ASER19
BSER19

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:11158243, ECO:0000269|PubMed:8175657
ChainResidueDetails
ASER45
BSER45

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:11158243, ECO:0000269|PubMed:8175657, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER59
BSER59

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; partial => ECO:0000269|PubMed:11369851, ECO:0000269|PubMed:22120592
ChainResidueDetails
ALYS92
BLYS92

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22120592
ChainResidueDetails
ALYS166
BLYS166

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:28939839
ChainResidueDetails
ASER41
BSER41

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250|UniProtKB:P23928
ChainResidueDetails
ATHR170
BTHR170

237735

PDB entries from 2025-06-18

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