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2KKW

SLAS-micelle bound alpha-synuclein

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004860molecular_functionprotein kinase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006469biological_processnegative regulation of protein kinase activity
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010517biological_processregulation of phospholipase activity
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0022898biological_processregulation of transmembrane transporter activity
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032410biological_processnegative regulation of transporter activity
A0032496biological_processresponse to lipopolysaccharide
A0032769biological_processnegative regulation of monooxygenase activity
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097435biological_processsupramolecular fiber organization
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903284biological_processpositive regulation of glutathione peroxidase activity
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AASP2
AHIS50

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
ASER87

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
ATYR125

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
ASER129

219140

PDB entries from 2024-05-01

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