2KJH
NMR based structural model of the UBCH8-UBIQUITIN complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000151 | cellular_component | ubiquitin ligase complex |
A | 0000209 | biological_process | protein polyubiquitination |
A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016740 | molecular_function | transferase activity |
A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
A | 0019941 | biological_process | modification-dependent protein catabolic process |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032020 | biological_process | ISG15-protein conjugation |
A | 0032446 | biological_process | protein modification by small protein conjugation |
A | 0036211 | biological_process | protein modification process |
A | 0042296 | molecular_function | ISG15 transferase activity |
A | 0043130 | molecular_function | ubiquitin binding |
A | 0045087 | biological_process | innate immune response |
A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
B | ARG54 | |
B | ARG72 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Essential for function |
Chain | Residue | Details |
B | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
B | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
B | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
B | CYS76 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
B | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
B | CYS76 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
B | LYS11 | |
B | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
B | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
B | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
B | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
B | LYS63 |