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2K7O

Ca2+-S100B, refined with RDCs

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0005102molecular_functionsignaling receptor binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0007155biological_processcell adhesion
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0008270molecular_functionzinc ion binding
A0008284biological_processpositive regulation of cell population proliferation
A0008360biological_processregulation of cell shape
A0016529cellular_componentsarcoplasmic reticulum
A0031643biological_processpositive regulation of myelination
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043167molecular_functionion binding
A0044548molecular_functionS100 protein binding
A0045666biological_processpositive regulation of neuron differentiation
A0046872molecular_functionmetal ion binding
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048708biological_processastrocyte differentiation
A0050786molecular_functionRAGE receptor binding
A0050806biological_processpositive regulation of synaptic transmission
A0051384biological_processresponse to glucocorticoid
A0051597biological_processresponse to methylmercury
A0060291biological_processlong-term synaptic potentiation
A0071456biological_processcellular response to hypoxia
A0097490biological_processsympathetic neuron projection extension
A1990138biological_processneuron projection extension
A1990845biological_processadaptive thermogenesis
A2001015biological_processnegative regulation of skeletal muscle cell differentiation
B0001726cellular_componentruffle
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0007155biological_processcell adhesion
B0007611biological_processlearning or memory
B0007613biological_processmemory
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008360biological_processregulation of cell shape
B0016529cellular_componentsarcoplasmic reticulum
B0031643biological_processpositive regulation of myelination
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043167molecular_functionion binding
B0044548molecular_functionS100 protein binding
B0045666biological_processpositive regulation of neuron differentiation
B0046872molecular_functionmetal ion binding
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048708biological_processastrocyte differentiation
B0050786molecular_functionRAGE receptor binding
B0050806biological_processpositive regulation of synaptic transmission
B0051384biological_processresponse to glucocorticoid
B0051597biological_processresponse to methylmercury
B0060291biological_processlong-term synaptic potentiation
B0071456biological_processcellular response to hypoxia
B0097490biological_processsympathetic neuron projection extension
B1990138biological_processneuron projection extension
B1990845biological_processadaptive thermogenesis
B2001015biological_processnegative regulation of skeletal muscle cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 101
ChainResidue
ASER18
AGLU21
AASP23
ALYS26
AGLU31

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 102
ChainResidue
BGLU31
BSER18
BGLU21
BASP23
BLYS26

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 103
ChainResidue
AASP61
AASP63
AASP65
AGLU67
AGLU72

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 104
ChainResidue
BASP61
BASP63
BASP65
BGLU67
BGLU72

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DEDGDGECDfqEF
ChainResidueDetails
AASP61-PHE73

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDedgDgecDFqEFmaFV
ChainResidueDetails
AVAL56-VAL77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305|PubMed:14621986
ChainResidueDetails
BHIS15
BHIS25
BHIS85
BHIS90
AHIS15
AHIS25
AHIS85
AHIS90

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18949447, ECO:0007744|PDB:2K7O
ChainResidueDetails
ASER18
AGLU21
ALYS26
AGLU31
BSER18
BGLU21
BLYS26
BGLU31

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:18949447, ECO:0007744|PDB:2K7O
ChainResidueDetails
AASP61
AASP63
AASP65
AGLU67
AGLU72
BASP61
BASP63
BASP65
BGLU67
BGLU72

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P02638
ChainResidueDetails
ASER1
BSER1

218500

PDB entries from 2024-04-17

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