2K40

NMR structure of HESX-1 homeodomain double mutant R31L/E42L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0030900	biological_process	forebrain development

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LAqkLnLEldRIQIWFqNrraklK

Chain	Residue	Details
A	LEU34-LYS57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	DNA_BIND: Homeobox => ECO:0000255|PROSITE-ProRule:PRU00108

Chain	Residue	Details
A	GLY1-HIS60

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