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2K40

NMR structure of HESX-1 homeodomain double mutant R31L/E42L

Functional Information from GO Data
ChainGOidnamespacecontents
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0003677molecular_functionDNA binding
A0006355biological_processregulation of DNA-templated transcription
A0030900biological_processforebrain development
Functional Information from PROSITE/UniProt
site_idPS00027
Number of Residues24
DetailsHOMEOBOX_1 'Homeobox' domain signature. LAqkLnLEldRIQIWFqNrraklK
ChainResidueDetails
ALEU34-LYS57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues59
DetailsDNA binding: {"description":"Homeobox","evidences":[{"source":"PROSITE-ProRule","id":"PRU00108","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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