2K07

Solution NMR structure of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1). Northeast Structural Genomics Consortium target HR41

Replaces:  1YWZ

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0007420	biological_process	brain development
A	0032649	biological_process	regulation of type II interferon production
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0061657	molecular_function	UFM1 conjugating enzyme activity
A	0061709	biological_process	reticulophagy
A	0070062	cellular_component	extracellular exosome
A	0071568	molecular_function	UFM1 transferase activity
A	0071569	biological_process	protein ufmylation
A	1990592	biological_process	protein K69-linked ufmylation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Glycyl thioester intermediate => ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:29868776, ECO:0000269|PubMed:34588452

Chain	Residue	Details
A	CYS116

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1) => ECO:0000269|PubMed:35926457

Chain	Residue	Details
A	LYS122

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