2JUT
alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
Functional Information from PROSITE/UniProt
| site_id | PS60014 |
| Number of Residues | 11 |
| Details | ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSdPRCR....YRC |
| Chain | Residue | Details |
| A | CYS2-CYS12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Peptide: {"description":"Alpha-conotoxin RgIA","featureId":"PRO_0000234830","evidences":[{"source":"PubMed","id":"16445293","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18242183","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18295795","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18945902","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21888386","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22774872","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25008370","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25393758","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25740413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Key residue for potent inhibition of the rat CHRNA9-CHRNA10 nAChR","evidences":[{"source":"PubMed","id":"18295795","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds to the Glu-221 of the rat nAChR CHRNA10 subunit","evidences":[{"source":"PubMed","id":"25740413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
