2JUL

NMR Structure of DREAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000287	molecular_function	magnesium ion binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0005267	molecular_function	potassium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006915	biological_process	apoptotic process
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009966	biological_process	regulation of signal transduction
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0019233	biological_process	sensory perception of pain
A	0032026	biological_process	response to magnesium ion
A	0032993	cellular_component	protein-DNA complex
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042803	molecular_function	protein homodimerization activity
A	0043523	biological_process	regulation of neuron apoptotic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0048265	biological_process	response to pain
A	0048266	biological_process	behavioral response to pain
A	0048306	molecular_function	calcium-dependent protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	0072659	biological_process	protein localization to plasma membrane
A	1901379	biological_process	regulation of potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	ASP175
A	ASN177
A	THR183

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	MET222
A	ASP223
A	ARG224

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINKDGCITkeEM

Chain	Residue	Details
A	ASP175-MET187
A	ASP223-PHE235

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Region: {"description":"Interaction with KCND2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"UniProtKB","id":"Q9Y2W7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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