2JT2

Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019637	biological_process	organophosphate metabolic process
A	0046872	molecular_function	metal ion binding
A	0103117	molecular_function	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
A	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 336

Chain	Residue
A	HIS74
A	HIS226
A	ASP230
A	C90501

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE C90 A 501

Chain	Residue
A	PHE180
A	ALA181
A	LYS190
A	GLY198
A	SER199
A	THR203
A	VAL205
A	HIS226
A	LYS227
A	ASP230
A	HIS253
A	ZN336
A	HIS19
A	HIS58
A	GLU73
A	HIS74
A	THR179

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15705580","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12819349","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15705580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---