2JQF

Full Length Leader Protease of Foot and Mouth Disease Virus C51A Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0004197	molecular_function	cysteine-type endopeptidase activity
R	0016032	biological_process	viral process
R	0019082	biological_process	viral protein processing
S	0004197	molecular_function	cysteine-type endopeptidase activity
S	0016032	biological_process	viral process
S	0019082	biological_process	viral protein processing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763, ECO:0000269|PubMed:9857201

Chain	Residue	Details
R	ALA51
R	HIS148
S	ALA251
S	HIS348

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763

Chain	Residue	Details
R	ASP163
S	ASP363

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by leader protease => ECO:0000255

Chain	Residue	Details
R	LYS201
S	LYS401

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
R	ASN46	electrostatic stabiliser, polar interaction
R	ALA51	electrostatic stabiliser, polar interaction
R	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
R	ASP163	electrostatic stabiliser, hydrogen bond donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
S	ASN246	electrostatic stabiliser, polar interaction
S	ALA251	electrostatic stabiliser, polar interaction
S	HIS348	hydrogen bond acceptor, proton acceptor, proton donor
S	ASP363	electrostatic stabiliser, hydrogen bond donor

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