2JQ3

Structure and Dynamics of Human Apolipoprotein C-III

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005769	cellular_component	early endosome
A	0006629	biological_process	lipid metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0006869	biological_process	lipid transport
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008289	molecular_function	lipid binding
A	0010897	biological_process	negative regulation of triglyceride catabolic process
A	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
A	0010916	biological_process	negative regulation of very-low-density lipoprotein particle clearance
A	0010987	biological_process	negative regulation of high-density lipoprotein particle clearance
A	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
A	0015485	molecular_function	cholesterol binding
A	0016042	biological_process	lipid catabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0032489	biological_process	regulation of Cdc42 protein signal transduction
A	0033344	biological_process	cholesterol efflux
A	0033700	biological_process	phospholipid efflux
A	0034361	cellular_component	very-low-density lipoprotein particle
A	0034363	cellular_component	intermediate-density lipoprotein particle
A	0034366	cellular_component	spherical high-density lipoprotein particle
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0034382	biological_process	chylomicron remnant clearance
A	0042157	biological_process	lipoprotein metabolic process
A	0042627	cellular_component	chylomicron
A	0042632	biological_process	cholesterol homeostasis
A	0043691	biological_process	reverse cholesterol transport
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0045833	biological_process	negative regulation of lipid metabolic process
A	0048261	biological_process	negative regulation of receptor-mediated endocytosis
A	0050995	biological_process	negative regulation of lipid catabolic process
A	0055102	molecular_function	lipase inhibitor activity
A	0060621	biological_process	negative regulation of cholesterol import
A	0070062	cellular_component	extracellular exosome
A	0070328	biological_process	triglyceride homeostasis
A	0070653	molecular_function	high-density lipoprotein particle receptor binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	Region: {"description":"Lipid-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"May interact with the LDL receptor","evidences":[{"source":"PubMed","id":"18408013","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","featureId":"CAR_000168","evidences":[{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23527852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3123586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---