2JPT

Structural changes induced in apo-s100a1 protein by the disulphide formation between its CYS85 residue and b-mercaptoethanol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0008016	biological_process	regulation of heart contraction
A	0016529	cellular_component	sarcoplasmic reticulum
A	0042311	biological_process	vasodilation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044548	molecular_function	S100 protein binding
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0051117	molecular_function	ATPase binding
A	1903672	biological_process	positive regulation of sprouting angiogenesis
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0008016	biological_process	regulation of heart contraction
B	0016529	cellular_component	sarcoplasmic reticulum
B	0042311	biological_process	vasodilation
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044548	molecular_function	S100 protein binding
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0051117	molecular_function	ATPase binding
B	1903672	biological_process	positive regulation of sprouting angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BME A 94

Chain	Residue
A	CYS85

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BME B 94

Chain	Residue
B	CYS85

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Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDGDGEVDfqEY

Chain	Residue	Details
A	ASP62-TYR74

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site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. VMkeLDedgDgevDFqEYvvLV

Chain	Residue	Details
A	VAL57-VAL78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P35467

Chain	Residue	Details
A	LYS27
A	GLU32
B	LYS27
B	GLU32

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	ASP62
B	GLU73
A	ASP64
A	ASP66
A	GLU68
A	GLU73
B	ASP62
B	ASP64
B	ASP66
B	GLU68

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Blocked amino end (Gly) => ECO:0000269|PubMed:7250124

Chain	Residue	Details
A	GLY1
B	GLY1

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P23297

Chain	Residue	Details
A	CYS85
B	CYS85

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