2JPA

Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 131

Chain	Residue
A	CYS9
A	CYS14
A	HIS27
A	HIS31

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 132

Chain	Residue
A	CYS39
A	CYS44
A	HIS57
A	HIS61

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 133

Chain	Residue
A	CYS72
A	HIS85
A	HIS89
A	CYS69

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 134

Chain	Residue
A	CYS97
A	CYS102
A	HIS115
A	HIS119

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CaypgCnkrYfklshlqmHsrk..H

Chain	Residue	Details
A	CYS9-HIS31
A	CYS39-HIS61
A	CYS69-HIS89
A	CYS97-HIS119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	PHE7-HIS31

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	TYR37-HIS61

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	PHE67-HIS89

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	ZN_FING: C2H2-type 4 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Important for interaction with target DNA

Chain	Residue	Details
A	ARG108
A	ARG114

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15520190

Chain	Residue	Details
A	ARG5

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